摘要 |
<p>The invention concerns alkanoic acid derivatives of the formula I <CHEM> wherein Ar<1> is optionally-substituted phenyl or naphthyl, or a 10-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur; A<1> is a direct link to X<1> or is (1-3C)alkylene; X<1> is oxy, thio, sulphinyl or sulphonyl; n is 0, 1 or 2 and R<1> is halogeno, (1-4C)alkyl, (1-4C)alkoxy or fluoro-(1-4C)alkyl; each of R<2> and R<3> is (1-4C)alkyl, (2-4C)alkenyl or (2-4C)alkynyl; and R4 is hydrogen or (1-4C)alkyl; or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.</p> |