| 摘要 |
Novel glutarylamino acid derivative dual inhibitors of neutral endopeptidase and angiotensin converting enzyme of the formula <IMAGE> wherein: R1 and R3 are independently hydroxy, lower alkoxy, aryllower alkoxy, amino, lower alkylamino and di-(lower alkyl)amino; R2 is H or hydroxy; R4 is aryl, substituted aryl, heteroaryl or substituted heteroaryl; R6 is H or R7-(CH2)3-, wherein R7 is amino or (aryllower alkoxy)carbonylamino; Q is -C(O)- or -SO2-; Y is lower alkyl, lower alkoxy, aryllower alkoxy, amino, lower alkylamino, di-(lower alkyl)amino, or a group of the formula <IMAGE> wherein A is a bond, -N(R5)-, or -O-; and R5 is H or lower alkyl; B is H or Z-(CH2)m- Z is amino, lower alkylamino, di-(lower alkyl)amino, (aryllower alkoxy)carbonylamino, 1-pyrrolidino or 1-piperidino; m=1,2,3,4 or 5; and n=1,2 or 3; or or a pharmaceutically acceptable addition salt thereof; useful in the treatment of cardiovascular disorders, are disclosed.
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