摘要 |
<p>A compound of the formulae <CHEM> where at least one R is -(A)<sb>p</sb>-R2 where (A)<sb>p</sb> is a linking group and R2 is a hypoxia localizing noiety; and wherein the other R groups are the same, or different and are independently selected from hydrogen, halogen, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, aryl, -COOR3, <CHEM> -NH2, hydroxyalkyl, alkoxyalkyl, hydroxyaryl, haloalkyl, arylalkyl, -alkyl-COOR3, -alkyl-CON(R3)2, alkyl-N(R3)2, -aryl-COOR3, -aryl-CON(R3)2, -aryl-N(R3)2, 5- or 6-membered nitrogen- or oxygen-containing heterocycle; or two R groups taken together with the one or more atoms to which they are attached form a carbocyclic or heterocyclic, saturated or unsaturated spiro or fused ring which may be substituted with R groups; R1 is hydrogen, a thiol protecting group or -(A)<sb>p</sb>-R2; R3 is hydrogen, alkyl or aryl; m = 2 to 5; p = 0 to 20 A)<s</p> |
申请人 |
E.R. SQUIBB & SONS, INC. |
发明人 |
LINDER, KAREN;NUNN, ADRIAN D.;NOWOTNIK, DAVID P.;RAMALINGAM, KONDAREDDIAR;DI ROCCO, RICHARD J.;RUMSEY, WILLIAM L.;PIRRO, JOHN P. |