IMMUNOSTIMULIERENDE PEPTIDE, DEREN VERFAHREN ZUR HERSTELLUNG UND SIE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN.

摘要

The peptides of formula I A - x - Lys - y - B I in which: A is H, a tripeptide of formula Arg-Ala-Arg or an hexapeptide of formula Glu-Lys-Arg-Arg-Ala-Arg x and y, different one from the other, are an arginine (Arg) or a glutamic acid (Glu) residue; B is OH or a tripeptide Arg-Ala-Arg with the proviso that when A is hydrogen and x is Arg, B is different from OH comprising the steps of: a) binding the Boc-protected carboxyterminal aminoacid to a suitable resin; b) reacting the other Boc-protected aminoacids with the resin-bound carboxyterminal aminoacid in the desired sequence; c) removing the protecting groups and releasing the so obtained peptides from the resin, have valuable pharmacological properties as immunostimulating agents.