发明名称 |
PROCESS FOR PRODUCING ANTIVIRAL TETRAHYDROIMIDAZO BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS |
摘要 |
Tetrahydroimidazo[1,4]benzodiazepines of formula <CHEM> wherein R<1> is C1-6alkyl optionally substituted with aryl; C3-6alkynyl; C3-6cycloalkyl; or a radical of formula: <CHEM> R<2>, R<3> and R<7> are hydrogen or C1-6alkyl; R<4> and R<5> are hydrogen, C1-6alkyl, halo, cyano, nitro, trifluoromethyl, hydroxy, C1-6alkyloxy, amino, mono- or di(C1-6alkyl)amino, (C1-6alkyl or aryl)carbonylamino; R<6> is C1-6alkyl; and X is OH, SH or NR<1><6>R<1><7>; the acid addition salts and stereochemically isomeric forms thereof; said compounds having antiretroviral activity. Pharmaceutical compositions comprising said compounds as active ingredient and methods of preparing said compounds and pharmaceutical compositions. |
申请公布号 |
HUT62297(A) |
申请公布日期 |
1993.04.28 |
申请号 |
HU19920000816 |
申请日期 |
1990.09.06 |
申请人 |
JANSSEN PHARMACEUTICA N.V.,BE |
发明人 |
KUKLA,MICHAEL JOSEPH,US;BRESLIN,HENRY JOSEPH,US;RAEYMAEKERS,ALFONS HERMAN MARGARETHA,BE;VAN GELDER,JOSEPHUS LUDOVICUS HUBERTUS,BE;JANSSEN,PAUL ADRIAAN JAN,BE |
分类号 |
C07D487/02;A61K31/415;A61K31/55;A61K31/551;A61K31/5517;A61P31/12;A61P37/04;C07D;C07D243/14;C07D487/04;C07D487/06 |
主分类号 |
C07D487/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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