(2-CYAN-2-OXIMINOACETYL)-AMINOSAEURE-DERIVATE.

摘要

(2-cyano-2-oximinoacetyl) amino acid derivs. of formula (I) and their geometric and optical isomers and isomer mixts. are new. R = (cyano)alkyl or opt. substd. alkenyl, alkynyl, cycloalkyl(alkyl) or phenyl-alkyl; R1 = -ACOOR2 or -BCONR3R4; A and B = each opt. substd., opt. branched alkylene; R2 = alkyl (substd. by halo, OH, alkoxy, acyloxy, opt. substd. aryl, opt. substd. cycloalkyl or opt. substd. heterocyclyl; R3 = alkyl, substd. by halo, CN, COOR1, CONR''R''', NR''R''', ORiv, S(O)nRiv, acyl, opt. substd. aryl, heterocyclyl, cycloalk(en)yl, or R3 is opt. substd. alkenyl, alkynyl, cycloalk(en)yl, aryl, or heterocyclyl; and R4 is as R3 but can also be a polycyclic carbocycle or ORiv; or R3 = H or alkyl and R4 = alkyl opt. substd. by acyl, OH, alkylcarbonyloxy, -S(O)nRiv, opt. substd. heterocyclyl, cycloalk(en)yl, or R4 is opt. substd. cycloalkenyl, heterocyclyl, or polycyclic carbocycle or substd. cycloalkyl, providing halo and alkyl are not the only substits., or R4 is ORiv; or NR3R4 form a substd. monocyclic heterocycle or an opt. substd. bi- or tricyclic heterocycle or spiro heterocycle contg. 1-3 furher opt. different heteroatoms; R1 = H or alkyl opt. substd. by halo, opt. substd. aryl, cycloalk(en)yl; R'' and R''' = each or alkyl opt. substd. by halo, COORiv, CONR'Riv, opt. substd. aryl, cycloalk(en)yl; or R'' and R''' are alkenyl, alknynyl or opt. substd. cycloalkyl, cycloalkenyl, aryl or heterocyclyl or NR''R''' form an opt. substd. heterocycle which opt. contains further heteroatoms; Riv = H, (ar)alkyl or acyl; n = 0-2.