发明名称 |
Preparation method of microdispersed tablet formulation of spray-dried sodium diclofenac enteric-coated microcapsules |
摘要 |
A preparation method of sodium diclofenac enteric-coated microcapsules by spray drying technique comprising the steps of (a) dissolving sodium diclofenac in an appropriate amount of distilled water; (b) adding an effective amount of excipients to the above solution to form a suspension; (c) adding methacrylic acid-ethyl acrylate copolymers (Eudragit L 30D) and polyethyleneglycol 6000 (PEG 6000) as the enteric-coating material to form a slurry; (d) atomizing the slurry to form spray-dried powder; (e) mixing the spray-dried powder with a mixture of microcrystalline cellulose (neocel) and pregelatinized starch (flo-starch); and (f) compressing the powder mixture into a microdispersed enteric tablet. The spray drying technique could be easily performed to prepare the enteric-coated microcapsules with aqueous latex polymer dispersion such as Eudragit L 30D as an enteric-coating polymer.
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申请公布号 |
US5202159(A) |
申请公布日期 |
1993.04.13 |
申请号 |
US19900636121 |
申请日期 |
1990.12.31 |
申请人 |
STANDARD CHEMICAL & PHARMACEUTICAL CORP., LTD. |
发明人 |
CHEN, LI J.;CHEN, CHUN N.;LIN, SHAN Y. |
分类号 |
A61K9/22;A61K9/16;A61K9/20;A61K9/26;A61K9/52;A61K9/58;A61K9/62;A61K31/19;A61K31/195;A61K47/38;A61P29/00 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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