| 发明名称 |
4-QUINOLINE CARBOXYLIC ACID DERIVATIVES USEFUL AS IMMUNOSUPPRESSIVE AGENTS |
| 摘要 |
<p>4-Quinolinecarboxylic acids and derivatives thereof, such as 2-(2 min -fluoro-1,1 min -biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, are useful as immunomodulatory and anti-inflammatory agents. Pharmaceutical formulations containing such compounds are useful for the treatment of autoimmune diseases, transplantation rejection, graft vs. host disease, and chronic inflammatory disease such as rheumatoid arthritis.</p> |
| 申请公布号 |
EP0339485(B1) |
申请公布日期 |
1993.03.31 |
| 申请号 |
EP19890107099 |
申请日期 |
1989.04.20 |
| 申请人 |
THE DU PONT MERCK PHARMACEUTICAL COMPANY |
发明人 |
ACKERMAN, NEIL RICHARD;JAFFEE, BRUCE DONALD;LOVELESS, SCOTT EDWARD;NEUBAUER, RUSSELL HOWARD |
| 分类号 |
C07D215/52;A61K31/47;A61P29/00;A61P37/00;A61P37/06;C07D409/04 |
主分类号 |
C07D215/52 |
| 代理机构 |
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