发明名称 |
INHIBITORS OF THROMBIN |
摘要 |
This invention relates to novel biologically active molecules which bind to and inhibit thrombin. Specifically, these molecules are characterized by a thrombin anion-binding exosite association moiety (ABEAM); a linker portion of at least 18 ANGSTROM in length; and a thrombin catalytic site-directed moiety (CSDM). This invention also relates to compositions, combinations and methods which employ these molecules for therapeutic, prophylactic and diagnostic purposes.
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申请公布号 |
US5196404(A) |
申请公布日期 |
1993.03.23 |
申请号 |
US19900549388 |
申请日期 |
1990.07.06 |
申请人 |
BIOGEN, INC.;HEALTH RESEARCH, INC. |
发明人 |
MARAGANORE, JOHN M.;FENTON, II, JOHN W.;KLINE, TONI |
分类号 |
A61K38/55;A61K38/00;A61K51/00;A61L33/00;A61P7/02;A61P29/00;A61P35/00;C07K7/02;C07K7/06;C07K7/08;C07K14/00;C07K14/81;C07K14/815;C12N9/99;G01N33/60;G01N33/68 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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