发明名称 |
Methods for identifying the DQw3.2 allele associated with increased risk of insulin-dependent diabetes mellitus |
摘要 |
Methods for identifying individuals at increased risk of diabetes are disclosed. The methods disclosed utilize the discovery of the DQw3.2 variant, which identifies a specific allelic polymorphism at a sinle gene locus. One preferred method utilizes a labeled probe to detect the DQw3.2 allele. This method involves estimating the size of the hybridizable DNA fragment generated by a specific restriction endonuclease and therefrom determining the presence of the allele. A second preferred method involves the serologic detection of the DQw3.2 allele. Within this method, immunocomplexes formed between two different MAb's and separate portions of a cell collection are detected and the presence or absence of the allele determined.
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申请公布号 |
US5196308(A) |
申请公布日期 |
1993.03.23 |
申请号 |
US19890325058 |
申请日期 |
1989.03.13 |
申请人 |
GENETIC SYSTEMS CORPORATION |
发明人 |
NEPOM, GERALD T.;NEPOM, BARBARA S. |
分类号 |
G01N33/53;C07K14/005;C07K14/195;C07K16/00;C07K16/28;C07K19/00;C12N15/00;C12N15/02;C12P21/00;C12P21/08;C12Q1/68;G01N33/543;G01N33/577 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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