PREPARATION OF A CEPHALOSPORIN ANTIBIOTIC USING THE SYN-ISOMER OF A THIAZOLYL INTERMEDIATE

摘要

CT-2179A The present invention provides an aqueous acylation process for the preparation of antibiotic, cefepime dihydrochloride hydrate which is substantially free of the anti-isomer and the .DELTA.2 isomer comprising the N-acylation of 7-amino-3-¢(1-methyl-l-pyrrolidinio)-methyl!ceph-3-em-4-carboxylate with the syn-isomer of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetyl chloride hydrochloride.