发明名称 |
PSEUDOPENTAPEPTIDES WITH IMMUNOMODULATING ACTIVITY |
摘要 |
Pseudopeptides of formula ( alpha ) wherein AA1 is an arginyl residue; AA2 is a basic amino acid residue, a neutral/nonaromatic amino acid residue or proline residue or is an N-alkylated (1-6C) form thereof; AA3 is an aspartic acid or glutamic acid wherein the remaining carboxyl group may be esterified with alkyl (1-6C), or an alanine residue; AA4 is a neutral/nonaromatic amino acid residue; AA5 is a neutral/aromatic amino acid residue wherein one or more hydrogens of its aromatic portion can be substituted by NO2 or halogen, or is a neutral/nonpolar/large/nonaromatic amino acid residue or the N-alkylated (1-6C) form thereof; R is acyl (1-6C), arylsulfonyl, alkylsulfonyl, arylalkylsulfonyl or alkoxycarbonyl group; and R1 is -OH, -NR2R3 or -OR4 wherein each of R2 and R3 is hydrogen or an alkyl group (1-6C) and R4 is alkyl group (1-6C); and wherein at least one of the linkages I-IV is a modified peptide linkage -COCH2-, -CH(OH)CH2- or -CH2NH-, and the remaining linkages are -CONH- or -CON(CH3)-. |
申请公布号 |
WO9304080(A1) |
申请公布日期 |
1993.03.04 |
申请号 |
WO1992JP01046 |
申请日期 |
1992.08.19 |
申请人 |
JAPAN TOBACCO INC. |
发明人 |
DEGRAW, JOSEPH, I.;ALMQUIST, RONALD;HIEBERT, CHARLES;SMITH, R., LANE;UCHIDA, ITSUO, |
分类号 |
A61K38/00;A61P37/00;C07K5/02;C07K5/06;C07K5/08;C07K5/10;C07K7/02;C07K14/66;G01N33/53 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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