The present invention provides analogs of hirudin having at least one amino acid in positions 30 to 37 substituted with Tyr and the native Tyr<3> and Tyr<63or64> residues substituted with a first and a second functional non-reactive amino acid.
申请公布号
WO9304082(A1)
申请公布日期
1993.03.04
申请号
WO1992US06910
申请日期
1992.08.17
申请人
BAXTER INTERNATIONAL INC.
发明人
KU, CECILIA, S., L.;JOHNSON, RICHARD;BREILLATT, JULIAN
