| 摘要 |
2115840 9303697 PCTABS00020 Prazosin is formulated in solution with a skin permeation enhancer composition of: a sulfhydryl-containing compound, a fatty acid ester, and a polar solvent for transdermal administration to treat hypertension or benign prostatic hypertrophy. The formulation is employed in the form of a skin patch (10) comprising (a) an impermeable backing layer (11), (b) a reservoir (12) of the prazosin-enhancer solution, (c) a porous support member (13) that retains the solution but is not a permeation barrier to the solution, a peripheral adhesive layer (14) for affixing the patch to the skin, and a release liner layer (15).
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