| 摘要 |
<p>The present invention provides conjugates useful for modifying target cell functions to achieve therapeutic results. Conjugates of the present invention may include a noncytolytic toxin that does not directly inhibit protein synthesis and is capable of operating through an existing cellular metabolism signaling mechanism; and a targeting moiety that constitutes a ligand recognized by the target cell receptor involved in that existing signaling mechanism. Alternatively, conjugates of the present invention may include a toxin domain capable of directly impacting a target cell metabolic process (e.g., catalyzing conversion of ATP to cAMP) or acting on a substrate that is implicated in such a process (e.g., actin); and a targeting moiety exhibiting specificity for the target cell population. Methods of using these conjugates are also discussed.</p> |
