ACTINOMYCETE TRANSFORMATION WITH SITE-SPECIFIC INTEGRATING FUNCTION OF PHAGE 0C31

摘要

The present invention provides a method for transforming an actinomycete with an integrating vector which has the advantages of high transformation rates into a broad host range, site-specific integration, and stable maintenance without antibiotic selection. Also provided are methods for the increased production of antibiotics and for the production of hybrid antibiotics.