发明名称 |
IGF-II ANALOGUES |
摘要 |
Insulin-like Growth Factor II (IGF-II) analogues in which at least one of R37 and R38 is replaced with another amino acid residue, the most preferred being IGF-II R37Q R38Q, can readily be produced in E. coli, unlike natural IGF-II, which is cleaved on secretion. The analogues retain activity on the type I and type II IGF receptors but have lower affinity for the insulin receptor; they are therefore more specific in their action. |
申请公布号 |
WO9303152(A1) |
申请公布日期 |
1993.02.18 |
申请号 |
WO1992GB01389 |
申请日期 |
1992.07.27 |
申请人 |
BRITISH BIO-TECHNOLOGY LIMITED |
发明人 |
EDWARDS, RICHARD, MARK;BAWDEN, LINDSAY |
分类号 |
A61K38/00;C07K14/65;C12N1/21;C12N9/08;C12N15/16 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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