INTERMEDIATES FOR THE PREPARATION OF HEXAHYDRO-1H-QUINO(4,3,2-EF)(1,4) BENZOXAZEPINES AND RELATED COMPOUNDS, A PROCESS AND THEIR USE AS MEDICAMENTS

摘要

The present invention relates to hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds, of formula wherein R<1> is H, alkyl, or benzyl; R is a group of the formula wherein Y is H, H or O, R<2> is H, alkyl, or phenyl, and Z is O or S; wherein Z of the group of the formula is bound to either the A- or B-position of the heteroaromatic nucleous; X is H, halogen, alkoxyl, alkyl, or trifluoromethyl; and n is 1, 2 or 3; a process for their preparation and intermediates thereof. The compounds of the invention are able to relieve memory dysfunction, particularly dysfunctions associated with decreased cholinergic activity such as those found in Alzheimer's disease and can, therefore, be used as medicaments.