PURIFICATION OF RECOMBINANT CILIARY NEUROTROPHIC FACTOR AND C-TERMINAL TRUNCATED CILIARY NEUROTROPHIC FACTOR AND METHODS FOR TREATING PERIPHERAL NERVE DAMAGE

摘要

Methods are provided for the production and purification of recombinant ciliary neurotrophic factor. The purification of C-terminal truncated forms of ciliary neurotrophic factor are also described. Methods are provided for preventing and treating peripheral nerve damage. The method comprises administering to patients in need thereof a therapeutically effective amount of CNTF. A preferred method for producing CNTF is by recombinant DNA technology.