A process for the glycosylation of avermectin compounds at the 14a-position.

摘要

Avermectin compounds are glycosylated the 14a- position by adding the avermectin compounds to the fermentation medium of Bacillus subtilis . The 14a-methyl group of the avermectin compound is glycosylated with a glycosyl moiety, specifically a glucose group. The compounds are potent anthelmintic and antiparasite agents, and compositions for such uses are also disclosed.