| 摘要 |
<p>The invention relates to microparticles containing an antimalarial drug such as primaquine, one of its amino acid derivatives or their conjugates with a hepatotropic carrier or their pharmaceutically acceptable salts, and a biocompatible and biodegradable polymer controlling the kinetics of release of the drug, such as DL-polylactide. …<??>The invention also relates to pharmaceutical compositions containing the microcapsules according to the invention. …<??>Lastly, the invention relates to processes for preparing microparticles as defined above, wherein:… - the polymer is dissolved in a volatile solvent,… - the drug and, where appropriate, a substance regulating the size of the microparticles are added to this solution,… - following evaporation, the microparticles are recovered by centrifugation and filtration.</p> |
