THIAZOLIDINE DERIVATIVES AND THEIR USE AS ANTI-VIRAL COMPOUNDS

摘要

The present invention provides compounds of formula (I), wherein R1 is hydrogen, alkyl or CH¿2?alkyl where the alkyl portion is substituted by OH; A represents either a group CHR?21CHR22¿OH or a group (II), where R21 is hydrogen, alkyl, cycloalkylalkyl or Aralkyl, R22 is hydrogen, alkyl, cycloalkylalkyl, aralkyl, CHR?24CONR25R26¿ (where R24 is hydrogen, alkyl, cycloalkylalkyl or Aralkyl, R25 is hydrogen or methyl and R26 is hydrogen, alkyl optionnally substituted by one or two hydroxyl groups, aryl, heteroaryl, cycloalkylalkyl, Aralkyl wherein the alkyl portion is optionnally substituted by hydroxymethyl, or Hetalkyl) or CHR?24NHCOR27¿ (where R27 is alkyl, cycloalkylalkyl or an aralkyl), R23 is alkoxy or NR28R29 (where R28 is hydrogen or methyl and R29 is hydrogen, alkyl, aryl, aralkyl or cycloalkylalkyl); X is a group -CHR?30(CHR31)¿r(CHR32)sCHR33-, where R?30 and R33¿ are hydrogen, r is 1, s is zero and R31 is hydroxyl or hydroxymethyl, or R?30 and R33¿ are hydrogen, r and s are 1 and R?31 and R32¿ are each hydrogen or hydroxyl provided that at least one of R?31 and R32¿ is hydroxyl, or one of R?30 and R33¿ is hydrogen and the other is hydroxymethyl and r and s are zero; useful in chemotherapy, particularly of viral infections.