| 摘要 |
PURPOSE:To simply and efficiently produce the subject compound by asymmetrically alkylating an aldehyde compound having an alkoxy group at the beta position with a dialkyl zinc in the presence of an optically active amino alcohol compound as a catalyst. CONSTITUTION:An aldehyde compound having an alkoxy group at the beta position is dissolved in a solvent such as hexane or THF, mixed with an optically active compound of formula II (R, R' are H, aliphatic hydrocarbon, aromatic hydrocarbon, etc.; * exhibits an optically active carbon) (e.g. dibutyl norephedrine) and further with a dialkyl zinc (e.g. diethyl zinc), stirred at room temperature for 10-20hrs and subsequently mixed with 1N hydrochloric acid to stop the reaction, followed by extracting the reaction solution and drying the extract to provide the objective compound of formula III [R<1> is hydrocarbon, trialkyl silyl of formula: R<3>R<4>R<5>Si (R<3>-R<5> are alkyl); R<2> is aliphatic hydrocarbon, cyclic aliphatic hydrocarbon, etc.] such as 5-benzyloxy-3-hexanol. |
