Antiviral compounds and antihypertensive compounds

摘要

Compounds useful as antihypertensive agents, or antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: <IMAGE> (1.0) and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating hypertension or a viral infection using compounds represented by Formulas 1.0. Also disclosed is a compound of Structure B <IMAGE> B useful as an intermediate in producing compounds of Formula 1.0. A process for preparing the compounds of Formula 1.0 is also disclosed. In the process a compound of Structure B <IMAGE> B is reacted with an alkoxide R1O-M+ in a solvent comprising the corresponding alcohol R1OH of the alkoxide. Optionally, an organic cosolvent may be used with the solvent.