beta -amino acid derivatives

摘要

Non-peptidyl compounds characterized generally as cycloalkyl/cycloalkylkyl-N-terminal amino hydroxy beta -amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest of the formula <IMAGE> wherein R1 is selected from cycloalkyl and cycloakylalkyl groups, wherein said cycloalkyl group contains three to about eight carbon atoms and the acyclic alkyl portion of said cycloakylalkyl group contains one to about eight carbon atoms; wherein each of R2 and R4 is independently selected from hydrido and methyl; wherein R3 is methyl or ethyl; wherein R5 is cyclohexylmethyl; wherein R6 is hydroxy; and wherein R7 is isobutyl or ethyl; or a pharmaceutically-acceptable salt thereof.