发明名称 |
Phosphonic acid derivatives, production and use thereof. |
摘要 |
<p>A phosphonic acid derivative compound represented by formula [I] or a pharmaceutically acceptable salt thereof: <CHEM> wherein R1, R2 and R3 each represent hydrocarbon groups which may be substituted, except cases in which (1) R2 is unsubstituted methyl, (2) R3 is an unsubstituted hydrocarbon group having 1 to 3 carbon atoms, and (3) R1 is benzyloxycarbonylaminomethyl, R2 is isobutyl and R3 is isobutyl or phenylmethyl, which has endothelin-converting enzyme inhibiting activity and is useful as pharmaceutical drugs such as therapeutic agents for hypertension, cardiac or cerebral circulatory diseases and renal diseases.</p> |
申请公布号 |
EP0518299(A2) |
申请公布日期 |
1992.12.16 |
申请号 |
EP19920109769 |
申请日期 |
1992.06.10 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
WAKIMASU, MITSUHIRO;MORI, MASAAKI;KAWADA, AKIRA |
分类号 |
A61K38/00;A61K38/55;A61P9/00;A61P9/12;A61P13/02;A61P15/00;C07K1/06;C07K1/113;C07K5/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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