发明名称 |
PROCESS OF PREPARING HIGHER ORDER CUPRATE COMPLEXES |
摘要 |
This invention encompasses a process for preparing higher order cuprate complexes which contain a carbanion for the formation of carbon to carbon bonds in reactions such as 1,4-conjugate addition. The complex is formed by reacting a first cuprate complex with a stannane such that the carbanion to be used to form carbon to carbon bonds is transferred from the stannane to the first cuprate complex to form a different higher order cuprate complex. This process permits the in situ preparation of a higher order cuprate complex having the carbanion desired to be used in a synthetic reaction. Higher order cuprate complexes prepared by this process are particularly useful for the efficient preparation of pharmacologically active prostaglandins. |
申请公布号 |
CA1311490(C) |
申请公布日期 |
1992.12.15 |
申请号 |
CA19880568869 |
申请日期 |
1988.06.07 |
申请人 |
SEARLE (G. D.) & CO. |
发明人 |
CAMPBELL, ARTHUR L.;BEHLING, JAMES R. |
分类号 |
C07B37/04;C07C67/00;C07C401/00;C07C405/00;C07F1/08;C07F7/18;C07F7/22 |
主分类号 |
C07B37/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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