THIOPYRANO (2,3,4-C,D) INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS

摘要

111/GL44 112/GL45 113/GL46 114/GL47 145/GL54 18311 TITLE OF THE INVENTIQN Thiopyrano¢2,3,4-c,d!indoles as Inhibitors of Leukotriene Biosynthesis Compounds having the formula I: I are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, psoriasis, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.