发明名称 |
PYRIDONECARBOXYLIC ACID DERIVATIVE |
摘要 |
<p>Known synthetic antibacterials having a condensed pyridonecarboxylic acid skeleton include quinolone derivatives having various substituents at various positions of the skeleton. The possibility of the presence of diastereoisomerism in these derivatives, however, gives rise to a mixture of at least four diastereomers having properties differing from one another, resulting in the difficulty in applying the same as such as a medicine. Under these circumstances the present invention provides an antibacterial 1-(1,2-cis-2-fluorocyclopropyl) quinolone derivative represented by general formula (I) comprising a single diastereoisomer even when there are various diastereoisomers thereof. In formula (I), R<1> represents methyl, difluoromethyl, etc.; R<2> represents a saturated nitrogenous heterocyclic group; A represents C-X<3> or nitrogen; X<1> and X<2> represent each independently halogen; and X<3> and Z represent each hydrogen, etc.</p> |
申请公布号 |
WO9221659(A1) |
申请公布日期 |
1992.12.10 |
申请号 |
WO1992JP00687 |
申请日期 |
1992.05.27 |
申请人 |
DAIICHI PHARMACEUTICAL CO., LTD. |
发明人 |
HAYAKAWA, ISAO;KIMURA, YOUICHI;TAKAHASHI, HISASHI |
分类号 |
A61K31/435;A61K31/4375;A61K31/47;A61K31/4709;A61K31/4995;A61K31/55;A61P31/00;A61P31/04;C07D215/56;C07D401/04;C07D471/04;C07D487/04;C07D487/08;C07D519/00 |
主分类号 |
A61K31/435 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|