Novel sulfonamide derivatives.

摘要

A sulfonamide derivative of the general formula: wherein, R<1> represents (i) COOR<1><1>, (ii) CH2OR<1><2> or (iii) CONR<1><3>R<1><4>, wherein R<1><1> represents a hydrogen atom, alkyl group of from 1 to 20 carbon atom(s), carbocyclic ring unsubstituted or substituted by an alkyl or alkoxy group of from 1 to 4 carbon atom(s) or halogen atom, or steroid, R<1><2> represents a hydrogen atom or COR<1><5>, R<1><3> and R<1><4> each represent a hydrogen atom or alkyl group of form 1 to 4 carbon atom(s) or NR<1><3>R<1><4> represents an amino acid residue or heterocyclic ring, or R<1><5> represents an alkyl group of from 1 to 4 carbon atom(s) or phenyl group, Xb represents (i) bond, (ii) alkylene group of from 1 to 4 carbon atoms or (iii) alkenylene group of from 2 to 4 carbon atoms (with the proviso that @ CH=CHCH2 @ and @ CH2CH=CHCH2 @ are excluded), R<2b> represents (i) hydrogen atom, (ii) halogen atom or (iii) alkyl group of from 1 to 4 carbon atom(s), the configuration of a double bond between C5 and C6 in the general formula (B) is cis, cyclodextrin clathrates thereof, or non-toxic salts thereof in case that R<1><1> represents a hydrogen atom or NR<1><3>R<1><4> represents an amino acid residue, possess an antagonistic activity on TXA2, in particular, inhibit blood platelet aggregation and contraction of artery, and are, therefore, useful for prevention and/or treatment of inflammation, hypertension, thrombus, cerebral apoplexy, asthma, cardiac infarction, angina pectoris, cerebral infarction and death by aucte cardiac diseases in mammales, in particular in humans, which are induced by thromboxane A2.