PEPTIDE ANALOGUES OF INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) OR FACTOR 2 (IGF-2)

摘要

PCT No. PCT/AU88/00485 Sec. 371 Date Aug. 24, 1989 Sec. 102(e) Date Aug. 24, 1989 PCT Filed Dec. 20, 1988 PCT Pub. No. WO89/05822 PCT Pub. Date Jun. 29, 1989.Peptide analogues of insulin-like growth factor 1 and growth factor 2 are disclosed. When the analogue is an analogue of growth factor 1 the glutamic acid residue is absent from position 3 of the N-terminal and either the glutamic acid residue or the threonine residue adjacent to glutamic acid residue at position 3 is replaced by a different amino acid residue. When the peptide analogue is an analogue of insulin growth factor 2 the glutamic acid residue position 5 is absent. Preferred peptide analogues are disclosed. Methods of use in pharmaceutical and veterinary preparations are described.