ISLET CELL AUTOANTIGEN (GAD) FOR THE DETECTION OF PRECLINICAL DIABETES

摘要

The presence of autoantibodies against an approximately 67 kD islet cell autoantigen (67 kD autoantibodies) in serum may be determined by a method comprising contacting a serum sample with a higher molecular weight glutamic acid decarboxylase (hMr GAD) or a fragment thereof capable of binding 67 kD autoantibodies, and detecting any binding of autoantibodies to the hMr GAD.