OLIGONUCLEOTIDE ANALOGS CONTAINING THIOFORMACETAL LINKAGES

摘要

Modified oligomers containing at least one internucleoside linkage of the formula Y<1>CX2Y<2> wherein at least one of Y<1> and Y<2> is sulfur and the other is oxygen and wherein each X is the same or different and is a stabilizing substituent are disclosed. These oligomers show superior binding properties and are thus useful for binding target substances in therapeutic and analytical uses. Also disclosed are improved methods for synthesis of oligomers containing linkages of the general formula -YCX2Y- wherein each Y may be independently oxygen or sulfur.