| 摘要 |
<p>A microdialysis probe (10) for living tissue having respective inlet (12) and outlet (14), fluid impermeable tubes connected by a dialysis fiber membrane (16) permeable only to small molecular weight compounds. A U-shaped, loop probe tip configuration of the fiber membrane contains a biologically inert wire insertion (22) to prevent kinking and ensure continuous fluid flow through the tip. The length and/or inner diameter of the outlet tube (14) is selected with respect to a given flow rate to create an optimum positive fluid pressure inside the probe membrane tip sufficient to self-support the membrane during insertion and dialysis sampling. Alternative side-by-side and concentric probe configurations are described.</p> |
