| 摘要 |
PURPOSE:To obtain the objective compound in high yield and readily in production of a cyano compound useful as a raw material especially for medicines, agricultural chemicals and liquid crystal substance by cyanating a nucleophilic reaction accepting compound with a trisubstituted silylanilide by using a specific catalyst. CONSTITUTION:In cyanating a nucleophilic reaction accepting compound such as carbonyl compound, e.g. aldehyde or ketone, imine compound or nitroolefin compound, preferably aldehyde with a trisubstituted silylanilide, a Lewis base such as organic amine compound, organic phosphorus compound, organic arsenic compound or organic antimony compound, preferably cinchonine or a derivative thereof, especially a cinchonine derivative shown by the formula (Tb is trifluoromethanesulfonic acid residue) as an asymmetric synthetic catalyst to improve yield, especially optical yield of the objective compound. The catalyst for asymmetric synthesis is readily obtainable and more stably and inexpensively supplied than existing catalysts for asymmetric synthesis. |
