N-acetyl-para-aminophenol is prepared by contacting 4-hydroxyacetophenone oxime with a Beckmann rearrangement catalyst in an alkyl alkanoate reaction solvent. An integrated process is disclosed wherein 4-hydroxyacetophenone is reacted with a hydroxylamine salt and a base to obtain 4-hydroxyacetophenone oxime, the oxime product is extracted from the resulting reaction mixture with a substantially water-immiscible solvent, and the mixture of oxime and substantially water-immiscible solvent is contacted with a Beckmann rearrangement catalyst to produce N-acetyl-para-aminophenol. Novel Beckamnn rearrangement catalysts are used to limit by-product formation in the ester solvent.
申请公布号
US5155273(A)
申请公布日期
1992.10.13
申请号
US19900556589
申请日期
1990.07.20
申请人
HOECHST CELANESE CORPORATION
发明人
FRITCH, JOHN R.;FRUCHEY, O. STANLEY;HORLENKO, THEODORE;AGUILAR, DANIEL A.;HILTON, CHARLES B.;SNYDER, PHILLIP S.;SEELIGER, WILLIAM J.