METHODS AND COMPOSITIONS FOR THE TREATMENT OF MALIGNANCIES IN WHICH A PROTEIN KINASE IS ASSOCIATED

摘要

2078010 9113989 PCTABS00007 Methods and compositions are disclosed for the treatment of malignancies in which a protein tyrosine kinase is associated. The malignancies may be treated with a gene transfer vehicle capable of infecting malignant cells, wherein the gene transfer vehicle carries a DNA construct comprising a DNA sequence encoding a protein tyrosine phosphatase (PTPase). Suitable DNA sequences include those encoding wild type, or carboxyl terminus truncated, PTPases.