PROCESS FOR THE PREPARATION OF (D) 2-(D-METHOXY-2-NAPHTHYL) PROPIONIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND NEW INTERMEDIATES THEREFOR

摘要

(d)-2-(6-Methoxy-2-naphthyl)propionic acid and pharmaceutically acceptable salts thereof are prepared by resolving mixtures of (d)- and (1)-enantiomers of 2-(6-methoxy-2-naphthyl)propionic precursor acids or salts thereof with N-alkyl- or N-cycloalkyl-D-glucamines or salts thereof to isolate the corresponding (d)-2-(6-methoxy-2-naphthyl)propionic precursor acid which can be readily converted into (d)-2-(6-methoxy-2-naphthyl)propionic acid or a pharmaceutically acceptable salt thereof.