14,17(ALPHA)-ETHENO- AND -ETHANOESTRATRIENES, PROCESSES FOR THE PREPARATION OF THESE COMPOUNDS, AS WELL AS THEIR USE FOR THE PRODUCTION OF MEDICINAL AGENTS

摘要

Disclosed are novel 14,17 alpha -etheno- and -ethanoestratrienes according to general Formula I <IMAGE> (I) wherein X is a -CH2-CH2 or <IMAGE> R1 is a hydrogen atom, a C1- to C15-acyl, benzoyl, C1- to C15-alkyl, C3- to C9-cycloalkyl or alkylcycloalkyl group, and R2 is the grouping <IMAGE> wherein R3 and R4 independently of each other mean a hydrogen atom or a straight-chain or branched, optionally partially or completely fluorinated C1-C8-alkyl group, a process for their preparation, pharmaceutical preparations containing these compounds, as well as their use for the production of medicinal agents. The novel compounds exhibit strong antiestrogenic efficacy.