| 摘要 |
Pharmaceutical compositions for delivering an effective dose of an angiogenesis inhibitor consisting of a tetracycline such as a minocycline or chemically modified tetracycline retaining collagenase inhibitory activity but not antibacterial activity. The effective dosage for inhibition of angiogenesis based on in vitro testing is between one and 500 micromolar. The compositions are delivered topically, locally or systemically using implants or injection, alone or in combination with a chemotherapeutic agent such as beta -cyclodextrin. The composition is extremely selective for growth of endothelial cells, inhibiting growth, but is not cytotoxic at the effective dosages. |
