| 摘要 |
A novel and unique plasminogen activator inhibitor fragment is obtained from human umbilical vein endothelial cells which has the following characteristics: A. it is derived from a native t-PA inhibitor that binds to and inhibits the activity of t-PA, B. it is dissociated from a complex formed between said native t-PA inhibitor and t-PA, said complex existing in two distinct interconvertible conformations with molecular weight of about 88 KDa and 105 KDa, respectively, and being partially reversible in the presence of fibrin, C. it has a molecular weight of about 40 KDa when dissociated from the complex, and D. it has a novel partial N-terminal amino acid sequence when dissociated from the complex.
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