PREPARATION OF(1R(1ALPHA(Z),2BETA,3BETA,5ALPHA))-(+)-7-(5-(1,1'-BIPHENYL)-4-YL METHOXY-3-HYDROXY-2-(1-PIPERIDINYL)CYCLOPENTYL-4-HEPTENOIC ACID AND NOVEL INTERMEDIATES THEREOF

摘要

A process is described for the preparation of a compound of formula (1) or a salt thereof, which comprises reacting a compound of formula (2) (where A is a displaceable atom or group and R is a hydrogen atom or a C1-6alkyl or C7-20aralkyl protecting group) or a salt thereof, to replace the moiety A with a phenyl group, followed where necessary by removal of a C1-6alkyl or C7-20aralkyl protecting group and/or by salt formation. The replacement of A in formula (2) by a phenyl group may be effected with a compound PhX (3) wherein Ph represents phenyl and X is an atom or group as defined for A in formula (2) or X is a metal atom or metal-containing group or a group SiR min 3 (where R min is an alkyl or aryl group) provided that when A is -B(OH)2 X can only represent a conventional leaving group.