发明名称 |
SYNTHETIC POLYMERIC DRUGS |
摘要 |
SYNTHETIC POLYMERIC DRUGS A polymeric drug comprising an inert synthetic polymeric carrier combined through aminoacid or peptide spacers with a bioactive molecule, a targeting moietyand an optional cross-linkage, comprises: (a) 5.0 to 99.7 mol % of units derived from N-(2-hydroxypropyl)methacrylamide, (b) 0.2 to 20.0 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a bioactive moiety, (c) 0.1 to 94.8 mol % of units derived from N-methacrylamide, N-methacrylic acid or an N-methacryloylated aminoacid or peptide, to which are bound a determinant capable of interacting with spedific receptors on cell surfaces, (d) optionally, 0 to 5 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a linking group which is similarly attached to a similar peptide group attached to another polymer chain, and (e) optionally, as a bioassay label, 0 to 2 mol % of units derived fron N-methacryloylated tyrosinamide.
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申请公布号 |
CA1305053(C) |
申请公布日期 |
1992.07.14 |
申请号 |
CA19860498931 |
申请日期 |
1986.01.03 |
申请人 |
CESKOSLOVENSKA AKADEMIE VED;CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED |
发明人 |
KOPECEK, JINDRICH;REJMANOVA, PAVLA;STROHALM, JIRI;ULBRICH, KAREL;RIHOVA, BLANKA;CHYTRY, VLADIMIR;LLOYD, JOHN B.;DUNCAN, RUTH |
分类号 |
A61K38/00;A61K;A61K31/00;A61K31/70;A61K45/00;A61K47/00;A61K47/48;A61P35/00;(IPC1-7):A61K47/48 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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