发明名称 SEROTONIN ANTAGONISTS, THEIR PREPARATION AND MEDICATIONS CONTAINING THEM
摘要 This invention relates to compounds of formula: <IMAGE> (I) in which R1 denotes a 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by an optionally substituted phenyl, optionally substituted 3-indolyl or 3-(5-hydroxyindolyl) radical, a 1-piperazinyl radical substituted in the 4-position by an optionally substituted phenyl, 1,2-benzisothiazol-3-yl, 1,2-benzisoxazol-3-yl or 2-pyridyl radical, a piperidino radical substituted in the 4-position by an optionally substituted phenyl, bis(4-fluorophenyl)methylene, 4-fluorobenzoyl, optionally substituted 2-oxo-1-benzimidazolinyl, optionally substituted 3-indolyl or 3-(5-hydroxyindolyl) radical, by two phenyl radicals or a hydroxyl radical and an optionally substituted phenyl radical R2 denotes a radical SO2R4 in which R4 denotes an alkyl or phenyl radical, R3 denotes a phenyl or naphthyl radical, or else R2 and R3 together with the nitrogen atom to which they are attached form a ring, n is equal to 2, 3 or 4, processes for their preparation and medications containing them. The invention relates to treating a disease ameliorated by serotonin.
申请公布号 US5130313(A) 申请公布日期 1992.07.14
申请号 US19900627101 申请日期 1990.12.13
申请人 RHONE-POULENC SANTE 发明人 COMTE, MARIE-THERESE;GUEREMY, CLAUDE;MALLERON, JEAN-LUC;PEYRONEL, JEAN-FRANCOIS;TRUCHON, ALAIN
分类号 C07D209/92;A61K31/425;A61K31/428;A61K31/445;A61K31/495;A61K31/54;A61P43/00;C07C311/08;C07C311/21;C07D211/70;C07D227/087;C07D275/06;C07D279/02;C07D285/16;C07D295/13;C07D401/04;C07D401/06;C07D401/12;C07D401/14;C07D413/12;C07D417/06;C07D417/12;C07D417/14;C07D471/04;C07D471/06;C07D487/06;C07D513/06 主分类号 C07D209/92
代理机构 代理人
主权项
地址