发明名称 |
TARGETING OF THERAPEUTIC AGENTS USING POLYSACCHARIDES |
摘要 |
The invention relates to a method for the targeting of a therapeutic agent to a specific population of cells, wherein a complex is formed between the therapeutic agent and a polysaccharide capable of interacting with a cell receptor, and wherein the resulting complex is internalized into the cell by receptor mediated endocytosis (RME). In one embodiment of the invention, a complex of a therapeutic agent containing iron and the polysaccharide arabinogalactan may be formed and used to deliver iron specifically to hepatocytes by RME. |
申请公布号 |
WO9211037(A2) |
申请公布日期 |
1992.07.09 |
申请号 |
WO1991US09368 |
申请日期 |
1991.12.13 |
申请人 |
ADVANCED MAGNETICS INC. |
发明人 |
JOSEPHSON, LEE;GROMAN, ERNEST, V.;JUNG, CHU;LEWIS, JEROME, M. |
分类号 |
A61K45/00;A61K47/36;A61K47/48;A61P15/00;A61P31/12;A61P43/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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