发明名称 TARGETING OF THERAPEUTIC AGENTS USING POLYSACCHARIDES
摘要 The invention relates to a method for the targeting of a therapeutic agent to a specific population of cells, wherein a complex is formed between the therapeutic agent and a polysaccharide capable of interacting with a cell receptor, and wherein the resulting complex is internalized into the cell by receptor mediated endocytosis (RME). In one embodiment of the invention, a complex of a therapeutic agent containing iron and the polysaccharide arabinogalactan may be formed and used to deliver iron specifically to hepatocytes by RME.
申请公布号 WO9211037(A2) 申请公布日期 1992.07.09
申请号 WO1991US09368 申请日期 1991.12.13
申请人 ADVANCED MAGNETICS INC. 发明人 JOSEPHSON, LEE;GROMAN, ERNEST, V.;JUNG, CHU;LEWIS, JEROME, M.
分类号 A61K45/00;A61K47/36;A61K47/48;A61P15/00;A61P31/12;A61P43/00 主分类号 A61K45/00
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