发明名称 |
Cyclic (hetero)acetals of nitro substituted benzaldehydes having anti-cancer activity. |
摘要 |
<p>New compounds having the general formula I <CHEM> wherein Y may be H or D; and A is H, D, alkyl with 1-4 C-atoms, halogen, nitro, amino, monoalkyl amino or dialkyl amino wherein the alkylgroups have 1-4 C atoms or OR wherein R is H or alkyl of 1-4 C-atoms; X1 and X2 may together with the carbon atom to which they are bound form a cyclic acetal, thioacetal, dithiane, aminal, oxazolidine or thiazolidine; or pharmaceutically acceptable salts thereof. The compounds are useful as anti-cancer agents.</p> |
申请公布号 |
EP0493883(A1) |
申请公布日期 |
1992.07.08 |
申请号 |
EP19910310790 |
申请日期 |
1991.11.22 |
申请人 |
NORSK HYDRO A.S. |
发明人 |
PETTERSON, ERIK OLAI;LARSEN, ROLF OLAV;BORRETZEN, BERNT;DORNISH, JOHN MICHAEL;OFTEBRO, REIDAR |
分类号 |
A61K31/335;A61K31/357;A61K31/375;A61K31/42;A61K31/421;A61K31/425;A61K31/426;A61K31/535;A61K31/5377;A61K31/54;A61K31/70;A61P35/00;C07D263/04;C07D263/06;C07D265/06;C07D277/04;C07D279/06;C07D317/16;C07D319/06;C07D407/04;C07H9/04 |
主分类号 |
A61K31/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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