| 摘要 |
NEW MATERIAL:A compound expressed by formula I (R<1> is H or carboxymethyl; R<2> is carboxyl, alkoxycarbonyl, lower alkyl, carboxyalkyl, cycloalkyl, etc.; X is -CH2-, -CO- or -SO2-). EXAMPLE:5-(1-Ethoxycarbonylmethyl-4-piperidinylidene) rhodanine. USE:An aldose reductase inhibitor. PREPARATION:A rhodanine (derivative) expressed by formula II is reacted with an 4-oxopiperidine compound expressed by formula III, preferably at a molar ratio of 1:1.1 to 1.5 in an organic solvent such as n-hexane at 50-150 deg.C. |
