TRIPLEX-FORMING OLIGOMERS CONTAINING MODIFIED BASES

摘要

Oligomers containing at least one modified nucleotide residue that specifically forms a triplet with the G-C doublet in forming a triplex with a target DNA duplex are disclosed which maintain this binding at neutral pH. The modified nucleotide residues have base components which provide donor H to each of the acceptable electron pairs at positions O6 and N7 of G at neutral pH. The oligomers may also have regions of inverted polarity and/or crosslinking moieties.