摘要 |
PURPOSE:To obtain the subject compound important as an intermediate for medicines, agricultural chemicals, and dyes in a high yield in short processes by nitrating a 1,3-difluoro-4,6-dihalogenobenzene, reducing the nitro group and subsequently removing the halogeno groups. CONSTITUTION:A compound of formula I (X is Cl, Br) obtained by chlorinating or brominating 1,3-difluorobenzene is nitrated by a conventional method to form a compound of formula II in which a nitro group is introduced between the chloro or bromo groups in high selectivity. The reduction and dehalogenation reaction are singly or continuously performed, preferably hydrogenated in the presence of a reduction catalyst (preferably Pd) and an agent for removing hydrogen halides for providing 3,5-difluoroaniline. |