| 摘要 |
2075970 9211294 PCTABS00014 Low molecular weight heparin derivatives and salts thereof are prepared by treating a quaternary ammonium salt of a heparin, dissolved in a heterocyclic organic solvent or in an aprotic solvent, with an alkylating agent having from 6 to 30 carbon atoms at a temperature of about 20· to 60 ·C for a prolonged period of time, treating the resultant reaction product at a temperature of about 5· to 120 ·C with an inorganic or organic base, such as an alkaline hydroxide, in aqueous solution, and isolating the obtained heparin derivatives in their free form or as alkaline salts thereof. The heparin derivatives obtained according to the procedure of the invention constitute a mixture of mostly depolymerized products with a narrow range of molecular weight. These products are useful as anti-thrombotic agents.
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